Name the question before comparing the method.
Different analytical methods answer different questions. HPLC is commonly used for separation and purity information, while mass spectrometry supports molecular-mass identity; neither replaces the written specification or lot context.
Method-to-question map
The exact method, sample preparation and acceptance criteria belong in the report and specification.
| Method or field | Question it commonly supports | Question it does not answer alone |
|---|---|---|
| HPLC | Chromatographic profile and reported purity | Full structural identity or every impurity |
| Mass spectrometry | Observed molecular mass versus expected mass | Purity percentage or product performance |
| Appearance | Visual description of the sample | Identity or analytical purity |
| Water content | Measured water in the sample | Peptide identity |
| Assay or content | Quantitative material content | Market approval or suitability |
| Microbial or safety test | The specific method and sample tested | Other untested attributes |
Read the method and the result together.
- Identify which method produced each result.
- Check units and acceptance limits.
- Compare the same method across suppliers where possible.
- Ask what the report does not cover.
What this route can and cannot confirm
Is mass spectrometry better than HPLC?
They answer different questions. Use both where the specification requires identity and purity information rather than treating one as a universal replacement for the other.
Can I compare two purity numbers without the method?
Not safely. Different methods, integration rules, wavelengths and sample preparation can change the meaning of a reported number.
Does ACTIVITY perform these tests?
No testing capability is implied by this page. Any service or independent laboratory must be identified and scoped in writing.
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